Pwytter – Portable Twitter Client
Pwytter is another great Stand Alone Twitter Client that can be run from a Portable USB Device. Some key Pwytter features include: Timeline switch, Friends and Followers list, Easy Replies and Direct Messages, In message URL detection, Automatic and manual refresh and more. Pwytter is also available in 14 languages.
Pwytter – Stand Alone Twitter Client

Authors Website: http://pwytter.com
License: Open Source
How to make Pwytter Portable:
- Download the Setup Pwytter exe
- Download Universal Extractor and unRaR it's contents to a folder on your desktop
- (1) Drag and Drop setup_pwytter_0.8.exe onto UniExtract.exe (2) Click OK

- Move the setup_pwytter_0.8/{app} folder from your desktop to your USB device
- Click pwytter.exe from the {app} folder to run the program
More information about the Universal Extractor can be found HERE
Some Antivirus Programs will trigger a false positve stating that the Universal Extractor contains a Worm. Please see the authors post for details.